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Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction

Kirke SM, Lowder S, Lloyd JJ, Diffey BL, Matthews JN, Farr PM

View on PubMed Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model Demonstrated AOD9604 intra-articular injection reduced cartilage degradation and inflammatory markers in a collagenase-induced knee osteoarthritis rabbit model, with the combination of AOD9604 and hyaluronic acid showing additive chondroprotective effects (Ann Clin Lab Sci, 2015)

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In controlled lab models, researchers have observed changes in fibroblast behavior when these cells are exposed to the peptide, including shifts in signaling activity tied to tissue structure